Background: In orthodontics, the various components of fixed appliances are fabricated by the use of varying materials which have their own physical and mechanical properties. Appliances become weak due to the action of all these agents and start releasing Ni, chromium, and so on, into the oral cavity. Hence; the present study was conducted for estimating salivary nickel (Ni) levels in patients undergoing orthodontic treatment. Materials & methods: A total of 35 patients who underwent fixed orthodontic treatment were enrolled. Cephlometric analysis was done in all the patients and treatment planning was done. All the patients were recalled in the morning before the starting of the study and salivary samples were obtained in test tubes. Fixed orthodontic treatment was started. All the patients were recalled after one month on follow-up and salivary samples were obtained again in the similar fashion. Third salivary samples were obtained on six months follow-up. All the samples were sent to laboratory were auto-analyser was used for assessment of salivary nickel levels. Results: At the baseline levels, mean salivary nickel levels were found to be 1.35 µg/L. At one month and six months follow-up, mean salivary nickel levels were found to be 5.58 µg/L and 3.49 µg/L respectively. While comparing the salivary nickel levels at different time intervals, significant results were obtained. Conclusion: Fixed orthodontic treatment results in transient rise in salivary nickel levels. Key words: Orthodontic, Nickel, Salivary