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Harsukh Educational Charitable Society International Journal of Community Health and Medical Research

Volume 6 Issue 1 Jan-March 2020

Original Articles

Evaluation of salivary copper and zinc levels in oral submucous fibrosis patients: A case-control study
Fasahat Husain, Ruchi Sharma, Ahmad Danish Rehan, Deepti Bhardwaj, Sameer Bhardwaj, Thippeswamy SH

Background: Oral submucous fibrosis (OSMF) precancerous condition and is chronic, resistant disease characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues. Zinc and copper have been the most extensively studied of the trace elements in patients with malignant disease and these elements in serum has been found to be reliable parameter as a diagnostic and prognostic index in case of craniofacial tumors. Hence; the present study was conducted for estimating the Salivary Trace Elements in OSMF Patients. Materials & Methods: A total of 30 patients with histological proven diagnosis of OSMF and 30 subjects (healthy controls) that came for routine dental checkup were enrolled in the present study. Complete demographic details of all the subjects were obtained. A Performa was made and complete habit history of all OSMF patients was obtained. All the patients were recalled in the morning and salivary samples were obtained. All the samples were sent to laboratory for assessment of salivary copper and zinc levels. Results: Mean salivary copper levels among the patients of the study group and control group was found to be 0.045 g/dL and 0.026 g/dL respectively. Mean salivary zinc levels among the patients of the study group and control group was found to be 0.418 g/dL and 0.194 g/dL respectively. Significant results were obtained while comparing the mean salivary copper and zinc levels among the patients of the study group and the control group. Conclusion: Copper and zinc are involved in the pathogenesis of the OSMF and hence can be used as a diagnostic maker. Key words: Oral submucous fibrosis, Copper, Zinc

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