Background: Diabetes is one of the biggest public health problem and epidemic in human history. Diabetes mellitus type 2 is the recent and most prevalent issue in the health problem and its prevalence is increasing rapidly. Lifestyle related risk factors play an important role in the development of type 2 diabetes mellitus. Some of these risk factors like dietary choices, smoking, and alcohol consumption, overweight and sedentary lifestyle are modifiable. Material and Methods: A comparative design was used to assess practices regarding lifestyle modifications among 200 diabetic patients out of which 100 subjects had taken from rural and 100 from urban area by using Purposive sampling technique. Data was collected with structured checklist to assess practices regarding lifestyle modifications by using interview method. Analysis was done by using descriptive and inferential statistics. Results: More than half (55%) and (63%) of diabetic patients had average practices regarding lifestyle modifications belonged to rural and urban area respectively whereas only 3% and 4% had good practices regarding lifestyle modifications belonged to rural and urban area respectively. Urban diabetic patients had more practices mean score (18.89±6.439) of lifestyle modifications than rural diabetic patients mean score (17.91±5.605).Conclusion- Urban diabetic patients had more practices of lifestyle modifications as per their mean difference than rural diabetic patients. Maximum lifestyle modifications occurred in area of diet, treatment, health learning, smoking and alcohol while the deficit areas were found to be physical activity, personal care and stress. Key words- Diabetes Mellitus type 2, Lifestyle modifications, diabetic patients