The present paper attempts to highlight a rare case of neural arborization in axilla. Anatomical Despite the development of high throughput technologies such as DNA microarrays, it now appears that IHC may play an increasing important role in clinical management of breast cancer. Various tumor markers for breast carcinoma are ER, PR, Her-2/neu, PCNA, Ki67, bcl2, p53, BRCA 1, BRCA 2, cyclin D, cyclin E, p21 protein, p27, Milk globule membrane antigen, Ki67, cathepsin D, E- cadherin, vimentin, beta catenin, carcino embryonic antigen (CEA) Oncotype Dx, B72.3, BCA 225. Hence, the present review discusses literature regarding various tumor markers and evalution of these markers will predict prognosis, disease free survival, genetic inheritance and aid in treatment planning. Keywords: Biomarkers; Immunohistochemistry; Hormonal therapy; Prognosis; Women nerve; Axilla