Background: The trifling illnesses in childhood such as fever, cough, and anaemia are very common Abstract 3 and frequently need medications such as antipyretic deiron syrups for these conditions. A high consumption of these oral medicinal syrups may be strongly associated with severe cases of dental erosion in childhood especially among children under age of 2 years. The present study was planned to comparatively analyse the erosive potential of paediatric liquid medicinal syrups on deciduous teeth.MATERIALS AND METHOD:A total of 20 extracted non-carious deciduous molars were selected for the study.To check the erosion potential of medicinal syrups, commonly used pediatric syrups were selected. The selected medicinal syrups included FeriumXT (for anaemia), Crocin syrup (antipyretic), Wikoryl syrup (cough syrup), and artificial saliva (control).RESULTS:The comparison of microhardness between four groups shows that there is a continuing loss of microhardness in all the groups on all days as compared to control group.Crocin was observed to be the most erosive with loss of microhardness from 301.16±0.72 on 7th day to 295.76±0.46 on 30th day. CONCLUSION:The evaluation of micro hardness of enamel showed that antitussive syrup (Ascoril-D) had highest erosive potential. Because of the regular need of these syrups for children and associated risk of tooth damage certain recommendations should be made to avoid the same like mouth rinsing with water;addition of calcium, fluoride, or phosphate to formulations; and consumption of the medication at meal times. Keywords: Decidous Teeth, Dental Erosion, Pediatric Syrups