Abstract Background:Oral Lichen Planus (OLP) is a relatively chronic T-cell-mediated inflammatory muco-cutaneous autoimmune disease. The present study was conducted to compare 0.1% Dexamethasone and 0.2% Triamcinolone acetonide mouthwashes for treatment of OLP.Materials & Methods: This study was conducted in year 2015 in patients with OLP.They were divided into 2 groups. Group I included 20 patients (males-10, females-10) who were given 0.1% Dexamethasone mouthwash. Group II included 20 patients (males-10, females-10) who were given 0.2% Triamcinolone acetonide mouthwashes. Diagnosis of OLP was made by the presence of clinical wickham’s striae followed by histology. The size of lesion and VAS score was compared in both groups.Results: Group I (0.1% Dexamethasone) included 20 patients (males-10, females-10) and group II (0.2% Triamcinolone acetonide) included 20 patients (males-10, females-10). The difference was non - significant (P > 0.05). Before treatment, the size of the lesion was 628 mm2 which at 1st week became 435 mm2, at 2nd week 217 mm2 and at 4th week it reduced to 109 mm.2 Whereas in group II, before treatment, the size of the lesion was 630 mm2 which at 1st week became 525 mm2, at 2nd week 302 mm2 and at 4th week it reduced to 132 mm.2 there was great reduction in size of lesion in group I but the difference was non – significant (P > 0.05). VAS score in group I before treatment was 6, at 1st week was 4, at 2nd week was 2 and at 4th week was 0. In group II, VAS score before treatment was 6.5, at 1st week was 5, at 2nd week was 3 and at 4th week was 0. There was fastest reduction in VAS score in group I but the difference was non - significant (P > 0.05). Conclusion: There was reduction in size of lesion with both 0.1% dexamethasone and 0.2% Triamcinolone acetonide. The VAS score also decreased with both the drugs. However, 0.1% dexamethasone showed better and faster results. Key words: Oral Lichen Planus, Dexamethasone, Triamcinolone acetonide