Background: Tooth wear can be classified as attrition, erosion and abrasion. Attrition is defined as the loss of enamel, dentin, or restoration by tooth-to-tooth contact. Erosion begins on the enamel surfaces and then proceeds to the underlying dentine if no timely intervention is instituted. In brief, the initial stage is softening of enamel surface and the degree varies with the immersion time and the type of acids involved. Subsequently, if the erosive attack continues, dissolution of enamel crystals takes place, which is a permanent loss with a rough layer on top of the remaining tissue. Aim of the study: To evaluate tooth dissolution in medicated liquid syrups. Materials and methods: The present study was conducted in the dental institution. Ten medicated syrups were selected. The study was in two parts: the pHs and titratable acidity of the syrups were evaluated and secondly, the weight loss of the test teeth was determined. 10 caries free human teeth were collected and sterilized in a 5% sodium hypochlorite (NaOCl) solution. Each specimen (test tooth) was weighed to 0.01 mg on a decicentimilligram balance. The teeth were assigned at random to the 10 syrups meant for evaluation. The control for the study was distilled water. Results: We observed that lowest pH was observed to be of CZ-3 Cold (4.6) followed by Ambrodil (4.65). Bro-Zedex and Bliskof had pH of 7.2 and 7.6 respectively. The highest pH was seen to be in Alpha Zedex (8.25). The loss of weight was seen to be significant in syrups with high acidic pH and observed to be mild in neutral and basic pH medicinal syrups. Conclusion: Within the limitations of the present study, it can be concluded that the pH of the liquid medicaments ranged between 4.6 and 8.25. The dissolution of tooth material was seen in all the samples but dissolution was more evident in medicines with acidic pH. Keywords: medicinal syrups, medicated liquids, tooth dissolution