Background: Periodontal infection is initiated by specific invasive oral pathogens that colonize dental plaque biofilms on tooth surface, and host immune response to inflammation plays a central role in disease pathogenesis. The differential diagnosis of perio-endo lesions has become increasingly important as the demand for complicated restorative work has grown. Hence; the present study was undertaken for assessing the pulpal changes in patients with periodontitis. Materials & Methods: A total of 100 patients with presence of severe chronic periodontitis were enrolled in the present study. 100 human teeth were obtained from patients with chronic periodontitis. Before extraction, thorough clinical examination was done along with radiographic analysis. All the extraction procedures were carried out under the hands of skilled and experienced oral surgeons. All the tooth specimens were sent for decalcification followed by histological analysis. Results: Pulp necrosis was found to be present in 75 percent of the patients. Pulp calcification was found to be present in 56 patients. Fibrosis and edema was found to be present in 25 patients and 19 patients respectively. Conclusion: Periodontal pathologies do have a deleterious effect on the pulp tissue. Key words: Endo- Perio, Pulp