Background: Management of pain following tooth extraction is a major concern. Pain is an adjuvant sequel to a surgical procedure which is commonly associated with inflammation. The present study compared diclofenac sodium and mefenamic acid in mandibular third molar surgery. Materials & Methods: The present study was conducted on 60 patients with impacted mandibular third molar requiring surgical extraction. Patients were divided into 2 groups, group I patients were prescribed 50 mg diclofenac sodium and group II patients were prescribed 500 mg mefenamic acid. All were advised to take these medications 3 times a day for 3 days. In both groups, pain in terms of VAS and mouth opening in mm was measured. Results: Group I received diclofenac sodium and group II received mefenamic acid. There were 25 males and 35 females I group I and 32 males and 28 females in group II. VAS pre- operatively in group I was 5.2 and in group II was 5.4 and after 3 days it was 2.1 in group I and 3.8 in group II. The difference was significant (P< 0.05). The mean mouth opening was 35.2 mm pre- operatively in group I and after 3 days was 45.1 mm. In group II was 35.8 mm pre- operatively and 41.3 mm after 3 days. The difference was significant (P< 0.05). Conclusion: Authors found that diclofenac sodium found to be effective than mefenamic acid in mandibular third molar surgery. Key words: Diclofenac, Mefenamic acid, Third molar