Background: Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable disease that is characterised by persistent respiratory symptoms and airflow limitation. Microalbuminuria could be a promising biomarker to identify patients with COPD at increased risk for poor cardiovascular outcomes. Hence; the present study was undertaken for assessing of microalbuminuria and its relationship with hypoxemia in patients of chronic obstructive pulmonary disease. Materials & methods: 100 patients of Chronic obstructive pulmonary disease diagnosed as per gold guidelines of COPD were included in the study. After taking proper history regarding hypertension, diabetes, fever, dysuria, any other co-morbid illness and smoking history (pack years), all the baseline parameters (like pulse, B.P, height, weight, BMI) shall be measured. Spirometry was recorded graphically and numerically. Microalbuminuria levels were compared between COPD cases and control groups by taking urine spot sample for analyzing UACR (urine albumin creatinine ratio) by strip method on CLINITEK urine analyser. An early morning urine sample will be preferred. Participants will be instructed to avoid heavy exercises 24 hrs before the test. All the results were analysed by SPSS software. Results: Microalbuminuria was found to be present in 57 percent of the COPD patients. Mean %predictive FEV1 and Pao2 of the COPD patients with Microalbuminuria was found to be 31.60 and 51.48 respectively and Mean %predictive FEV1 and Pao2 of the COPD patients without Microalbuminuria was found to 43.67 and 59.38 respectively. While comparing the mean % predictive FEV1 and Pao2 in between COPD patients with and without Microalbuminuria, significant results were obtained. While assessing the correlation of FEV1 and Microalbuminuria among COPD patients, significant results were obtained. Conclusion: Microalbuminuria may be seen in patients with COPD, depending on the severity of disease and hypoxemia. The determination of microalbuminuria is simple, inexpensive, and non-invasive. As such, it could be a promising biomarker to identify patients with COPD at increased cardiovascular risk. Key words: Microalbuminuria, Chronic obstructive pulmonary disease