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Harsukh Educational Charitable Society International Journal of Community Health and Medical Research

Volume 6 Issue 1 Jan-March 2020

Original Articles

Assessment of the timing of onset of CKD related metabolic complications
Rakesh Chander, Jithesh G, Tarsem Pal, Anil Batta, Raman Sharma, Ajay Chhabra, Surinder Pal, Kamalpreet Singh

Background: Chronic kidney disease is a precursor to end-stage kidney disease and is associated with an increased risk of death. The present study was conducted to assess the timing of onset of CKD related metabolic complications (anemia/hyperkalemia/ hyperphosphatemia/ hypocalcemia/metabolic acidosis) at different stages of CKD. Materials & Methods: The present study was conducted on 150 patients of CKD of both genders. Blood sample was collected in a dry disposable syringe under aseptic condition by vein puncture and arterial sample was collected by arterial puncture under aseptic condition. Biochemical assay was done in all patients. Results: Out of 150 patients, fatigue was seen in 69 patients (46%), muscle pain in 58 (38.7%), numbness in 52 (34.6%), bone pain in 48 (32%) and vomiting in 47 (31.2%). Maximum number of CKD patients was seen in CKD 5 which constitute 46% followed by CKD 4 which constitutes 20.6%. As the stage of CKD advances there is a significant occurrence of anemia, hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia and metabolic acidosis. The anemia hyper phosphatemia, hyperuricemia occurrence become significant from stage 3B onwards and the occurrence of hypocalcemia hyperkalemia and metabolic acidosis become significant from stage 4. Conclusion: Monitoring for anemia hyper phosphatemia, hyperuricemia are mandatory from stage 3 B and for hypercalcemia hyperkalemia and metabolic acidosis stage 4, so as to treat the patients effectively and retard the progression of CKD to some extent. Early diagnosis and management of these conditions may prevent or delay the progress to end stage renal disease. Key words: Bicarbonate, Chronic kidney disease, Serum phosphate.

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