Background: The lipids are important ingredients of cell membranes and play a vital role in numerous biological processes, including maintaining the integrity of the cell. Materials & Methods: In the perspective of this view, influences on levels of various serum lipid profile parameters, namely, Total cholesterol (TC), LDL cholesterol, VLDL cholesterol, HDL cholesterol, Triglycerides (Trg) have been discussed with an aim to establish an interrelationship between the above selected lipid profile variables for both oral and non oral cancer patient groups.Results: A good systematic and well pronounced declining trend in all the selected study plasma lipid parameters (VLDL, LDL, HDL, Trg and TC) is clearly visible from their relative deviation of average values of each lipid parameters of oral-cancer patient group to their observed values of non-oral cancer patient case. An overall declining level in percentage deviation of the each lipid parameters from non-oral cancer patient group to oral cancer patient cases has been observed to be higher (22%) for Trg parameter, followed by their intermediate values of 20% in VLDL, 18% in LDL, 16% in TC and their recorded lowest value of only 7% in HDL parameter. Furthermore, reduction in all such chosen lipid profile parameters, except in the case of the HDL, in oral cancer patient category relative to non oral cancer patient cases was found the best statistical significance levels, i.e., exceeding the confidence level above 95%. Conclusion:The lower plasma lipid status may be a useful bio-marker indicator for initial changes occurring in neoplastic cells. Keywords-High Density Lipid; Lipid Profile Parameters; Low Density Lipid; Cholesterol