Background: Successful endodontic therapy is critically dependent on the thorough removal of microorganisms and their by-products. The present study was conducted to assess efficacy of different obturation technique for root canal treatment. Materials & Methods: The present in vitro study was conducted on 90 single rooted extracted permanent teeth. Teeth were divided into 3 groups of 30 each. Group I used thermafil obturation technique, group II used warm vertical condensation obturation technique and group III used cold lateral condensation obturation technique. The percentage of gutta-percha filled area (PGFA) was calculated. Results: The mean percentage gutta percha filled area in group I was 98.3%, in group II was 97.1% and in group III was 95.2 %. The difference was significant (P< 0.05). Conclusion: Authors found that thermafil obturation technique had maximum gutta percha filled area than warm vertical condensation obturation and cold lateral condensation obturation technique. Key words: Thermafil, Obturation, lateral condensation