Background: There are several kinds of biomarkers, which are associated with peri-implantitis. Detection of proteomics biomarkers could intuitively and accurately determine the survival of oral microbes and their responses to the environment changes, including the osteocalcin, alkaline phosphatase, matrix metalloproteinases (MMPs), and C-reactive protein (CRP). Hence; the present study was undertaken for assessing the level of C reactive proteins in patients with peri-implantitis. Materials & methods: A total of 10 patients with clinical and radiographic evidence of peri-implantitis and 10 healthy controls were enrolled in the present study. Complete demographic details of all the patients were obtained. Thorough clinical examination of all the patients was carried out. All the patients were recalled in the morning in and GCF (gingival crevicular fluid) samples were obtained. All the samples were sent to laboratory where auto-analyser was used for evaluation of serum C reactive proteins levels. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software. Results: Mean C reactive proteins levels among the patients of the peri-implantitis group and the control group were found to be 397.4 pg/mL and 188.9 pg/mL respectively. While comparing statistically, it was observed that mean C reactive proteins levels of the patients of the peri-implantitis group was found to be higher in comparison to the patients of the control group. Conclusion: Patients with peri-implantitis have raised levels of C reactive proteins. Key words: C reactive proteins, Peri-implantitis