Background: The main goal of endodontic therapy is resolution and/or prevention of apical periodontitis, which can be achieved by thorough cleaning, disinfection, and filling in the three-dimensional context of the root canal system. A key to successful endodontics and a major goal of contemporary nonsurgical root canal treatment is to seal completely, both the apical and coronal avenues of potential leakage. Hence; the present study was undertaken for comparing the efficacy of carrier-based obturation technique and Lateral compaction (LC) technique in patients undergoing root canal therapy. Materials & methods: A total of 40 patients scheduled to undergo root canal therapy were enrolled. Assessment of peri-apical radiographs was done. All the patients were broadly divided into two study groups based on the type of obturation technique used as follows; Group 1 - Patients in which Carrier-based obturation (CO) technique was used and Group 2 – Patients in which Lateral compaction (LC) technique was used. All the root canal procedures were performed under the hands of skilled and experienced Endodontists. Clinical and radiographic evaluation of all the patients was done for assessing the prognosis. Results: Clinical and radiographic success was seen in 90 percent of the patients of group 1 while it was seen in 95 percent of the patients of group 2. While comparing statistically, non-significant results were obtained while comparing the efficacy of both the obturation techniques. Conclusion: In patients undergoing root canal therapy, both the obturation techniques can be used with equal effectiveness. However; further studies are recommended. Key words: Obturation, Root canal therapy