Background:-Obesity is one of the most common significant health hazards and is associated with autonomic dysfunction. Material and method:- In the present study, 40 obese subjects (body Mass Index >25 kg/m2) and 40 non-obese subjects (Body Mass Index <25kg/m2) were selected to study the effect of obesity on the sympathetic nervous system. To test the functioning of sympathetic nervous system in these groups, two non-invasive cardiovascular autonomic function tests -blood pressure response to standing and blood pressure response to sustained handgrip were performed. Results:- Result of both test were lower in obese subjects as compared to non obese subjects. But result of only sustained grip handgrip exercise shows significant result. Conclusion:-Thus, obesity is associated with altered sympathetic nervous system which may result in various cardiovascular complications. Keywords: Obesity, Autonomic Dysfunction, Body Mass Index, Cardiovascular Autonomic Function Test, Blood Pressure Response To Standing And Blood Pressure Response To Sustained Handgrip.