Background: The complex interaction of genetic and environmental factors is a common feature of MetS and COPD. The aim of this study was to investigate the frequency of MetS in patients with COPD and to assess the status of systemic inflammation in COPD patients with MetS and those without MetS. Material & Methods: A case control study done on 540 outdoor & indoor patients attending the department of Medicine with clinical history consistent with Chronic Obstructive Pulmonary Disease (COPD) and diagnosed so as per GOLD guidelines. Age, sex and BMI matched healthy subjects will form the control group. For NCEP criteria abdominal obesity is a component of the syndrome but not a prerequisite for diagnosis. The IDF criteria of MetS uses central obesity (waist circumference ≥90 cm for South Asian men or ≥80 cm for South Asian women) as a mandatory criterion and the presence of at least two of the other four criteria which are identical to those provided by NCEP ATP III. Results: Our study showed that the majority of cases were seen in 31-75 years in case group but in control group were seen in 15-75 years of age. The BMI, Life style, FBS, Blood pressure and lipid profile was not statistically significant. The grade 2 & grade 3 GOLD criteria of COPD was statistical significant with metabolic syndrome. Conclusion: The present study shows that MetS is frequent in patients with COPD. Management of these disorders should reduce the risk of cardiovascular morbidity and mortality in patients with COPD. Keywords: COPD, Met’s, GOLD Criteria, NCEP-ATPIII criteria