Background: Post-operative wound infection is an infection in the tissues of the incision and operative area. Surgical Site Infections (SSIs) have been responsible for the increasing cost, morbidity and mortality related to surgical operations and continue to be a major problem even in hospitals with most modern facilities and standard protocols of preoperative preparation and antibiotic prophylaxis. Aim: To study factors associated with post operative wound infections. Materials and Methods: 100 cases of post operative wound infections with different age group from several wards of Rajindra hospital, Patiala were studied. Detailed history from the patient including the risk factors associated with the wound was taken after obtaining informed written consent of the patient. Results: Out of the total of 100 cases, only 27 developed wound infection postoperatively giving an infection rate of 27%.The infection rate was maximum in the age group of 60-69 years i.e.60% and minimum in the age group of 20-29 years i.e.22.7%. The percentage of wound infection increased with the duration of operation. It was found that the infection rate was slightly higher in emergency surgeries (34.8%) as compared to elective ones (11.8%) with highest rate in case of abdominal laparotomy cases (39.3%) followed by appendicectomy and was more in drained wounds (34.3%) as compared to non drained ones(15.2%).Conclusion: The advances in the operative techniques and a better understanding on the pathogenesis of the wound infections, post-operative wound infections are still a major source of morbidity and mortality for the patients who undergo operative procedures. Key Words: Post-operative Wound infections; Surgical Site Infections