Background: The frequency of hip fracture has been increasing with an aging amongst population in different parts of the world, and the quantity of hip fractures is expected to influence around 512,000 in the year 2040. The proximal femoral nail presented by the AO/ASIF group in the year 1998 and has become prevalent in managing trochanteric fractures in the recent years. The present study was conducted to prospectively assess the Efficacy of Dynamic Hip Screw and Proximal Femoral Nail in the Treatment of Inter-Trochanteric Fracture of Femur. Materials and methods: The present study was conducted prospectively in the department of orthopedics for a duration of 1 year. A standard surgical procedure was used for the management of the subjects. Proximal femoral nail of 240mm was used. The total duration of surgery, amount of blood transfusion, amount of blood loss and the complications occurring intraoperatively were noted. Student test and chi square test were used to perform the statistical analysis. Probability value of less than 0.05 was considered as significant. Results: There were 40 subjects enrolled in the study, with 20 subjects in each group. The mean age of the subjects was 55.43 +/-2.89 years. The mean intraoperative time in Group I was 103.9±34.72 minutes and in group II was 87.7±21.7. There was no significant difference between the two groups. There were 3 cases of bed sore in Group I and no case of bed sore in Group II because of early mobilization. Two cases in both the groups presented with urinary tract infections. Conclusion: Out of the varied options available, the present study compared proximal femoral nailing and dynamic hip screw and found that there was no significant difference between the groups. The amount of blood loss varied significantly between the groups rest all variables showed insignificant difference. Keywords: Dynamic, Femoral Nail, Trochanteric