Background: Epilepsy is a vert prevalent and important neurological condition around the world. At least 50 million people around the globe are affected by the disorder and around 100 million people have experienced seizure at least once during their lives. oxidative stress is the chief reason behind the neurodegenerative conditions such as epilepsy.4-11 Vitamin E is found in the roots of wheat and vegetable oils. The most crucial portion of this substance is the α portion because it comprises of 90% of the tocopherol composition of the animal tissues. The present study was conducted with the aim to evaluate the role of tocopherol in the management of epilepsy cases. Materials and methods: The present prospective study was conducted in the Department for a period of 1 year. Subjects taking two anticonvulsant drugs in the past 6 months and having 2 seizures per month were included in the study. Patients taking carbamazepine, sodium valproate, levetiracetam, or a combination of them and not taking any Vitamin E supplement were enrolled in the study All the subjects underwent EEG before the beginning of the treatment. Regular follow ups were performed for a period of 6 months and EEG changes and biochemical markers were measured amongst them. Chi square and independent t test were used to compare the results. Probability value of less than 0.05 was considered as significant. Results: A total of 60 subjects were enrolled in the present study with 30 subjects in each group. The mean age of cases was 29.8+/-5.1 years and the mean age of controls was 29.6+/-8.2 years. There was no significant difference between the groups. The mean antioxidant capacity of cases before and after treatment was 6.3+/-2.2 mg/dl and 7.7+/-2.3 mg/dl respectively. The mean antioxidant capacity of controls before and after treatment was 7.4+/- 2 mg/dl and 7.3+/- 2.2mg/dl respectively. Conclusion: Increase in the oxidative stress can be implicated for causing brain damage and hence seizures. There was a considerable improvement in the seizure frequency amongst subjects that were given Vitamin E. Keywords: Neurological , Oxidative , Tocopherol