Introduction: Agriculture is one of the major occupations in India and millions of workers are involved in Abstract agriculture related activities. Due to exposure to multiple external factors, these workers are prone to develop various health problems and musculoskeletal disorders are one among them.Objectives: The study focused to find the prevalence and the factors associated with musculoskeletal disorders (MSDs) and to identify the remedies used by the agricultural workers to relieve the problems associated with MSDs.Methodology: A community based cross sectional study was conducted among 300 agricultural workers in a rural area of Tiruchirappalli, Tamil Nadu. Nordic Musculoskeletal Questionnaire was used to identify the presence of MSD and information on socio-demographic details, occupation, work activities and duration of work, self reported co morbidities and anthropometric measurements were taken. The data was analyzed using Epi info 7.2. The results of descriptive analysis and chi square test were presented in the form of mean and percentages. Results: Out of 300 agricultural workers, 53.7% were males. The mean age of the study group was 50.64±8.4 years. Musculoskeletal disorders were present among 84.3% of the study group. Low back ache was the most common (30.83%) musculoskeletal disorder followed by knee pain, problems in the shoulder, neck, upper back, hip, wrist and elbow. Significant association between the presence of MSD and age of the individuals, years of involvement in agricultural work was observed and there was no significant relation between MSD and gender and body mass index of the workers. Routine activities of 28% of the workers were affected due to presence of MSD. Only 56% of the workers with musculoskeletal disorder had medical consultation for their problem. Conclusion: Musculoskeletal disorders are significant health problem among agricultural workers which has potential to interfere with their occupational activities and also the routine work. Key words: agriculture, factors, musculoskeletal disorders, prevalence, workers