Background: Pulpotomy is one of the frequently performed procedures in primary molars in which there is no Abstract evidence of radicular pathology and the teeth are symptomless. In this the pulp present in the root stumps with an agent that promotes healing and fixes the underlying tissue. The first pulpotomy medicament used was formaldehyde in 1874 as formocresol by Sweets. The main aim of present study is to evaluate the effectiveness of pulpotomies using ferric sulphate, glutaraldehyde and MTA and to estimate the material which offers best results.Materials and Methods: The present study was conducted in the Institute, State during a period of 5 months i.e. May 2016- October,2016. Ethical committe clearance and informed consent was obtained. Patients were randomly divided into three groups. In Group I pulpotomy agent used was 15.5% ferric sulphate, in Group II pulpotomy agent used was 2% glutaraldehyde and in Group III, MTA was used. All the patients were evaluated clinically and radiographically after a period of 24 hours, 3 months and 6 months. All the data obtained was recorded in a tabulated form and analysed using SPSS software. Chi square test and Fischer t test was used for analysis. The results were considered significant if the p value was less than 0.05.Results: A total of 75 children took part in this randomised study. Each group had 25 children each. After a period of 24 hours, only one tooth was lost in Group II. This number increased to 9 after an interval of 3 months. After 3 months, one tooth was lost in Group I, 5 in Group II and 3 teeth in Group III. There was a loss of 29.3% teeth (22 teeth) after an interval of 6 months. In Group I, 75% of the patients presented with periodontal widening. In Group II, 65% of the patients showed periodontal widening and in Group III, only 4.5% patients demonstrated periodontal widening after a 3 month interval. The difference was statistically significant between the groups. Radiological evidence of periodontal widening was shown by 63% patients in Group I, 87.5% patients in Group II and 11.1% patients in Group III after an interval of 6 months. The difference was highly significant.Conclusion: It can be easily concluded from our study that MTA shows best result as pulpotomy medicament followed by 15.5% ferric sulphate and 2% buffered glutaraldehyde Keywords: Ferric sulphate, Glutaraldehyde, Pulpotomy, radicular